|
KMID : 1123920090230061392
|
|
Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 6 p.1392 ~ p.1398
|
|
|
Anti-inflammatory Effects of Sophora Japonica Aqueous Extract
|
|
Bae Gi-Sang
Jeon Ho-Seong
Kwon Kang-Beom
Kim Jae-Hyo
Park Sung-Joo
Jo Beom-Yeon
Kim Min-Sun
Park Kyoung-Chel
Koo Bon-Soon
Seo Sang-Wan
Kim Sung-Gyu
Yun Seung-Won
Jung Won-Seok
Ham Kyung-Wan
Song Ho-Joon
|
|
|
Abstract
|
|
|
|
The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Sophora Japonica (SJ) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of SJ, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa b (NF-kB) using Western blot. SJ inhibited LPS-induced production of NO, TNF-a but not of IL-1b and IL-6 in RAW 264.7 cells. SJ inhibited the activation of MAPKs such as extracelluar signal-regulated kinase (ERK 1/2), c-Jun NH2-terminal kinase (JNK) and p38 but not of NF-kB in the LPS-stimulated RAW 264.7 cells. In conclusion, SJ down-regulated LPS-induced NO and TNF-a productions via MAPKs, which could be a clinical basis for inflammatory diseases and autoimmune diseases.
|
|
|
KEYWORD
|
|
|
Sophora Japonica (SJ), lipopolysaccharide (LPS), inflammation, cytokine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|